Saturday Night Live (2/27/21) opened with a skit of a game show where participants try to get the COVID-19 vaccine. This is not the first satirical game show about diseases. The Firesign Theatre had a comedy routine on their 1968 album Waiting for the Electrician or Someone Like Him called :”Beat the Reaper”. Participants in the game show had to guess what disease they had in order to get the antidote.
Terry Southern‘s 1958 novel Flash and Filigree included a game show called “What’s My Disease?”. My copy is packed up but here are links to descriptions. The one on Southern’s archives states that he wrote a screenplay based on Nathanael West’s A Cool Million. I would love to see a film of that. I think it would be best as a Tim Burton-style animated film.